Dehydrated bodies also dry out more readily, possibly leaving an odorless, mummified carcass.īrodifacoum has a similar mode of action to warfarin. As such, there is less chance that homeowners will be forced to deal with decomposing remains inside their building. īrodifacoum, like most anticoagulant poisons, has the advantage that one of its first effects is dehydration, forcing the rodent to move away from human habitation in search of water. It is typically used as a rodenticide but is also used to control rabbits, possums and other mammalian pests. In recent years, it has become one of the world's most widely used pesticides. Oral dermal inhalation (dusts) (for poisoning)īrodifacoum is a highly lethal anticoagulant poison. In conclusion, the authors recommended vitamin K: therapy, 2 mg/kg by tablet or injection, daily for 3 weeks in cases of known or suspected brodifacoum poisoning in dogs.3-(3-(4'-bromobiphenyl-4-yl)-1,2,3,4- tetrahydro-1-naphthyl)-4-hydroxycoumarin The remaining 7 dogs showed various signs of anticoagulant poisoning 4 to 8 days after dosing and they received a 5 day course of vitamin Kr After this period one dog had a transient rise in its P time but this returned to normal without treatment, while another dog was treated on days 16,20,29 and 30. Two dogs died suddenly without pre¬monitory clinical signs of poisoning. Nine dogs received vitamin K: (2 mg/kg by intramuscular injection) when clinical signs of anticoagulant poisoning were observed. Four dogs were not given further vitamin Kj and two of these died of acute blood loss from an intrathoracic hemorrhage. It was necessary to give further doses of vitamin Kj to most of the dogs for up to 2 weeks after the first treatment period to reduce their P times to normal levels (seconds). Eleven were immediately treated with vitamin K: daily for 5 days, either by intramuscular injections (2 mg/kg) or oral tablets (1 mg/kg). Twenty dogs received a potentially lethal (15 mg/kg) dose of brodifacoum, a halogenated coumarin-type anticoagulant poison.
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